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  1. Adolescents living with HIV (ALHIV) aged 10–19 years endure sub-optimal viral load suppression (VLS) and retention in care in many settings. We implemented operation triple zero (OTZ) in The AIDS Support Organ...

    Authors: Bonniface Oryokot, Abraham Ignatius Oluka, David Kagimu, Yunus Miya, Saadick Mugerwa Ssentongo, Catherine Achola, Abubaker Kawuba, Twaha Mafabi, Charles Odoi, Baker Bakashaba, Kenneth Mugisha, Michael Bernard Etukoit and Eleanor Namusoke-Magongo
    Citation: AIDS Research and Therapy 2025 22:52
    Content type: Research Published on:

  2. HIV/AIDS persists as a global health challenge despite significant advancements in antiretroviral therapy (ART). The transformation of HIV into a chronic condition, coupled with regional disparities and evolvi...

    Authors: Yuanfang Chen, An-Dong Li, Yizhou Yang, Jing Lu, Yu Xu, Xinyu Ji, Liting Wu, Lei Han, Baoli Zhu and Ming Xu
    Citation: AIDS Research and Therapy 2025 22:51
    Content type: Research Published on:

  3. HIV/AIDS therapy continues to make an enormous contribution to improving the well-being of HIV/AIDS patients globally. In Gabon, dolutegravir is administered to HIV/AIDS patients from first-line treatment. Thi...

    Authors: Christian Mangala, Rolf Moukanda-Ifoundou, Denis Maulot-Bangola, Alain Moutsinga, Christian Mombo-Maganga, Serge Christian Okolongo-Mayani, Brice Ongali, Guy Joseph Lemamy and Rachyda Massolou-Outata
    Citation: AIDS Research and Therapy 2025 22:50
    Content type: Research Published on:

  4. Adherence to antiretroviral therapy (ART) and viral load suppression (VLS) constitute one of the key challenges to control human immunodeficiency virus (HIV), especially during adolescence. This trial aimed at...

    Authors: Alice Ketchaji, Joseph Fokam, Felix Assah, Francis Ateba, Martial Lantche Wandji, Joelle Nounouce Bouba Pamen, Godfroy Rostant Pokam Djoko, Cedric Dylan Nana Seugnou, Emmanuel Kah, Alain Fouda Atangana and Jerome Ateudjieu
    Citation: AIDS Research and Therapy 2025 22:49
    Content type: Research Published on:

  5. HIV status disclosure remains a major challenge among children living with perinatally acquired HIV with many taking treatment up to adolescence without knowing their serostatus. This non-disclosure is influen...

    Authors: Joseph Kirabira, Janet Nakigudde, Keng-Yen Huang, Scholastic Ashaba, Harriet Nambuya, Yesim Tozan and Lawrence H. Yang
    Citation: AIDS Research and Therapy 2025 22:48
    Content type: Research Published on:

  6. The rapid initiation of antiretroviral therapy has become an international trend, necessitating lifelong medication for all HIV patients. Sanger sequencing, as the gold standard for clinically detecting HIV dr...

    Authors: Chang Yan, Fengting Yu, Mengying Li, Xiaojie Yang, Rui Sun, Xuelei Liang, Xiaojie Lao, Hanxi Zhang, Wenhao Lv, Ying Hu, Yuan Lai, Yi Ding and Fujie Zhang
    Citation: AIDS Research and Therapy 2025 22:47
    Content type: Research Published on:

  7. Authors: Rosie Mngqibisa, Huichao Chen, Catherine Godfrey, Motshedisi Sebitloane, Unoda Chakalisa, Sharlaa Badal-Faesen, Gaerolwe Masheto, Frank Taulo, Wadzanai Samaneka, Jennifer Tiu, Cynthia Firnhaber and Timothy Wilkin
    Citation: AIDS Research and Therapy 2025 22:46
    Content type: Correction Published on:

    The original article was published in AIDS Research and Therapy 2024 21:101

  8. To evaluate long-term changes in weight and metabolic parameters in people with HIV-1 (PWH) initiating first-line antiretroviral therapy.

    Authors: Eric S. Daar, Chloe Orkin, Paul E. Sax, Debbie Hagins, Anton Pozniak, Kimberly Workowski, Cynthia Brinson, Juan Manuel Tiraboschi, Hui Liu, Chris Deaton, Cal Cohen, Sharline Madera, Jason T. Hindman and Moti Ramgopal
    Citation: AIDS Research and Therapy 2025 22:45
    Content type: Research Published on:

  9. HIV-1 remains a major global health challenge, impacting approximately 39 million people worldwide. Although antiretroviral therapy has substantially reduced HIV incidence and enhanced the quality of life for ...

    Authors: Sharana Mahomed, Kayla Pillay, Razia Hassan-Moosa, Bruna P. G. V. Galvão, Wendy A. Burgers, Penny L. Moore, Melissa Rose-Abrahams, Carolyn Williamson and Nigel Garrett
    Citation: AIDS Research and Therapy 2025 22:44
    Content type: Review Published on:

  10. Adolescents aged 10–19 years, living with HIV (ALHIV) lag in attaining optimal viral load suppression (VLS) rates and retention in care. This study aimed to identify barriers and facilitators to both treatment...

    Authors: Bonniface Oryokot, Andrew Kazibwe, Abraham Ignatius Oluka, David Kagimu, Baker Bakashaba, Saadick Mugerwa Ssentongo, Twaha Mafabi, Charles Odoi, Abubaker Kawuba, Yunus Miya, Bernard Michael Etukoit, Kenneth Mugisha and Eleanor Namusoke-Magongo
    Citation: AIDS Research and Therapy 2025 22:43
    Content type: Research Published on:

  11. The human immunodeficiency virus (HIV) increases susceptibility to measles, mumps, and rubella (MMR) infections due to decreased cluster of differentiation 4 + T-cell levels and rapid waning of protective anti...

    Authors: Sara Ghaderkhani, SeyedAhmad SeyedAlinaghi, Kousha Farhadi, Ladan Abbasian, Alireza Abdollahi, Malihe Hasannezhad, Seyed Ali Dehghan Manshadi and Erta Rajabi
    Citation: AIDS Research and Therapy 2025 22:42
    Content type: Research Published on:

  12. Cryptococcal infection remains a leading cause of mortality among HIV-1-positive individuals, particularly in regions with limited access to antiretroviral therapy and diagnostics. This study aimed to assess C...

    Authors: Bukhari Isah Shuaib, Amina Momodu, Fareedah Momodu and Bumojo Hope Agada
    Citation: AIDS Research and Therapy 2025 22:41
    Content type: Research Published on:

  13. HIV/AIDS remains a public health threat globally. The disclosure rates of positive HIV status by young people living with HIV (YPLHIV) to their sexual partners vary and have been reported as low as 31%, despit...

    Authors: Moses Mugerwa, Juliana Namutundu, Joanita Nangendo, Victoria Babirye Tumusiime, Denis Ndekezi, Collins G. K. Atuheire, Kelvin Bwambale, Suzanne N. Kiwanuka and David Kyaddondo
    Citation: AIDS Research and Therapy 2025 22:40
    Content type: Research Published on:

  14. The World Health Organization (WHO) has published guidelines for the management of patients with advanced HIV disease (AHD) but mortality remains high. Adoption of WHO recommendations by national guidelines is...

    Authors: Thomas C. Scheier, Tafese Beyene Tufa, Torsten Feldt, Yasmine Hardy, Albert Minga, Raoul Moh, Albertino Damasceno, Lucia Chambal, Francine Ntoumi, Carine Kades, Leopold Bitunguhari, Osee R. Sebatunzi, Marco Missanga, Katanekwa Njekwa, Monde Muyoyeta, Sumathy Rangarajan…
    Citation: AIDS Research and Therapy 2025 22:39
    Content type: Research Published on:

  15. Weight change for women living with HIV (WLWH) who receive dolutegravir (DTG) is understudied around pregnancy. The aim of this study was to investigate the direction and magnitude of weight change among WLWH ...

    Authors: Ammar Al Naimi, Charlotte Chang, Holly Rawizza, Oluwaseun Olaifa, Olabanjo Ogunsola, Prosper Okonkwo and Phyllis Kanki
    Citation: AIDS Research and Therapy 2025 22:38
    Content type: Research Published on:

  16. Advanced HIV disease (AHD) is increasingly becoming a threat to the survival of people living with HIV. Many countries, including Malawi, have adopted and adapted World Health Organization AHD management guide...

    Authors: Gift C. J Msowoya, Beatrice Matanje, Fabien Munyaneza, Jonathan Kalua, Basimenye Nhlema, Christopher Banda, Enoch Ndarama, Henry Ndindi, Jean Christophe Dimitri Suffrin, Charles Phiri, Limbani Thengo and Moses Banda Aron
    Citation: AIDS Research and Therapy 2025 22:37
    Content type: Research Published on:

  17. The burden of HIV infection among key population like female sex workers (FSW) is higher and challenges the prevention and control of the virus compared to other population groups. HIV self-testing allows peop...

    Authors: Kotu Merga, Tomas Benti, Gada Edea, Firaol Regea, Tesfu Zewdu and Hailu Merga
    Citation: AIDS Research and Therapy 2025 22:36
    Content type: Research Published on:

  18. Concerns of increased metabolic dysfunction have been heightened for HIV patients on long-term antiretroviral therapy (ART). Among first-line ART agents, Tenofovir alafenamide (TAF) may entail a marked increas...

    Authors: Hamed Mirmoezzi, Hamid Emadi Koochak, Seyed Ali Dehghan Manshadi, Malihe Hasannezhad, SeyedAhmad SeyedAlinaghi, Kiavash Semnani, Ladan Abbasian and Sara Ghaderkhani
    Citation: AIDS Research and Therapy 2025 22:35
    Content type: Research Published on:

  19. With the current elimination of mother to child transmission (EMTCT) of HIV, the number of HIV-positive newborns has greatly reduced. Some countries have successfully eliminated HIV infections among newborn ba...

    Authors: Immaculate Nankya, Eva Natukunda, Diana Rutebarika, Christine Matama, Roy Basiimwa, Paul Arikod, Faryad Muwabe, Caroline Otike and Cissy Kityo
    Citation: AIDS Research and Therapy 2025 22:34
    Content type: Research Published on:

  20. Antiretroviral therapy (ART) has significantly reduced HIV infections, but late initiation remains a major issue. This study aimed to identify predictors of ART initiation among newly diagnosed HIV-positive pa...

    Authors: Yobsan Girma, Ephrem Mannekulih, Hunde Lemi and Tesfaye Getachew Charkos
    Citation: AIDS Research and Therapy 2025 22:33
    Content type: Research Published on:

  21. Globally, differentiated care has been adopted across human immunodeficiency virus (HIV) treatment cascades as part of the strategies of increasing and sustaining retention in care. This study examined the imp...

    Authors: Azubuike A. Ekwuofu, Obinna F. Dim and Maxwell O. Adibe
    Citation: AIDS Research and Therapy 2025 22:32
    Content type: Research Published on:

  22. Vaccine acceptance among People Living with HIV (PLWH) is crucial for managing and mitigating the spread of infectious diseases, including Mpox. This systematic review and meta-analysis assess the rate of vacc...

    Authors: Ambanna Yappalparvi, Mahalaqua Nazli Khatib, Ashok Kumar Balaraman, M. M. Rekha, Mandeep Kaur, Girish Chandra Sharma, Puneet Sudan, K. Satyam Naidu, Rajesh Singh, Sonam Ramashankar, Karan Khati, Sanjay Singh Chauhan, Lokesh Verma, Amritpal Sidhu, Rachana Mehta, Renu Sah…
    Citation: AIDS Research and Therapy 2025 22:31
    Content type: Review Published on:

  23. HPTN 071 (PopART) implemented a comprehensive HIV prevention package which aimed to reduce HIV incidence within 21 communities of Zambia and South Africa: Arm A, PopART intervention of universal HIV testing an...

    Authors: Timothy M. Skalland, Jean de Dieu Tapsoba, Sahar Z. Zangeneh, Sian Floyd, Helen Ayles, Peter Bock, Sarah Fidler, Susan H. Eshleman, Richard J. Hayes and Deborah Donnell
    Citation: AIDS Research and Therapy 2025 22:30
    Content type: Brief Report Published on:

  24. Data on the impact of World Health Organization (WHO)’s guideline changes and COVID-19 on ART initiation in the Asia–Pacific remain scarce. This study described temporal trends from HIV diagnosis to ART initia...

    Authors: Thinh Toan Vu, Dhanushi Rupasinghe, Vohith Khol, Romanee Chaiwarith, Junko Tanuma, Nagalingeswaran Kumarasamy, Suwimon Khusuwan, IKetut Agus Somia, Sanjay Pujari, Man Po Lee, Rohidas T. Borse, Sasisopin Kiertiburanakul, Evy Yunihastuti, Iskandar Azwa, Jun Yong Choi, Hsin-Pai Chen…
    Citation: AIDS Research and Therapy 2025 22:29
    Content type: Research Published on:

  25. This study aimed to explore willingness to use and preference for long-acting injectable PrEP (LAI-PrEP) among Thai youth at risk of HIV. A cross-sectional study was conducted in 100 Thai youth aged 18 to 24 y...

    Authors: Alisa Wongsethanatada, Wipaporn Natalie Songtaweesin, Prissana Wongharn, Juthamanee Moonwong, Sasiprapha Khamthi, Lucksanapon Pitikawinwong and Thanyawee Puthanakit
    Citation: AIDS Research and Therapy 2025 22:28
    Content type: Research Published on:

  26. Simplified HIV treatment guidelines favor integrase strand transfer inhibitors (INSTIs). However, non-infectious comorbidities and co-occurring conditions (i.e. pregnancy) often necessitate individualized anti...

    Authors: Sonya Krishnan, Marina B. Martinez Rivera, Christopher K. Lippincott and Maunank Shah
    Citation: AIDS Research and Therapy 2025 22:27
    Content type: Brief Communication Published on:

  27. The burden of HIV remains disproportionally high among the adolescent girls and young women. This is often coupled with nondisclosure of HIV status partly due to delayed knowledge of HIV status which affects e...

    Authors: Edward Kumakech, Deo Benyumiza, Marvin Musinguzi, Wilfred Inzama, Ebong Doryn, James Okello, Lydia Kabiri, Vanja Berggren and Jasper Watson Ogwal-Okeng
    Citation: AIDS Research and Therapy 2025 22:26
    Content type: Research Published on:

  28. This Matters Arising explores the article titled “Willingness to Trade-Off Years of Life for an HIV Cure– An Experimental Exploration of Affective Forecasting,” published in AIDS Research and Therapy in August 20...

    Authors: Karine Dubé, Jeff Taylor, William Freshwater, Thomas J. Villa, David Palm, Derrick Mapp and Lynda Dee
    Citation: AIDS Research and Therapy 2025 22:25
    Content type: Matters Arising Published on:

  29. The growing number of older adults living with HIV, facilitated by wider access to antiretroviral therapy (ART), presents unique challenges. This study aims to identify predictors of survival among older perso...

    Authors: Christine Atuhairwe, Leonard Atuhaire, Stephen Ojiambo Wandera, Dinah Amongin, Titus Ochieng and Cyprian Misinde
    Citation: AIDS Research and Therapy 2025 22:24
    Content type: Research Published on:

  31. Despite progress towards HIV epidemic control, people living with HIV (PLHIV) in Zambia continue to face high mortality during and especially after hospitalization, with suboptimal post-discharge care leading ...

    Authors: Chiti Bwalya, Kirsten Stoebenau, Godfrey Muchanga, Mwangala Mwale, Choolwe Maambo, Swamie Banda, Palicha Halwiindi, Linah K. Mwango, Caitlin Baumhart, Nyuma Mbewe, Mundia Mwitumwa, Priscilla Mulenga, Manhattan Charurat, Wilbroad Mutale, Michael J. Vinikoor and Cassidy W. Claassen
    Citation: AIDS Research and Therapy 2025 22:22
    Content type: Research Published on:

  32. Advanced HIV disease (AHD) is still a significant problem in Uganda despite the test-and-treat strategy and the increased access to antiretroviral therapy (ART). Meningitis remains a major cause of morbidity a...

    Authors: Alisat Sadiq, Richard Kwizera, Tadeo K Kiiza, Peruth Ayebare, Cynthia Ahimbisibwe, Jane Frances Ndyetukira, David R Boulware and David B. Meya
    Citation: AIDS Research and Therapy 2025 22:21
    Content type: Research Published on:

  33. Hepatitis C virus (HCV) coinfection may further compromise immunological and cognitive function in people with HIV (PWH). This study compared laboratory and neuropsychiatric measures across the periods of HCV ...

    Authors: Ferron Ocampo, Carlo Sacdalan, Suteeraporn Pinyakorn, Misti Paudel, Tanyaporn Wansom, Nathornsorn Poltubtim, Somchai Sriplienchan, Nittaya Phanuphak, Robert Paul, Denise Hsu, Donn Colby, Lydie Trautmann, Serena Spudich and Phillip Chan
    Citation: AIDS Research and Therapy 2025 22:20
    Content type: Research Published on:

  34. Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus (EBV)-driven lymphoproliferative disease that usually arises in the context of reduced immunological surveillance. Based on histology, two forms o...

    Authors: Maria Kogan, Antonio Maria Alviano, Martina Catalano, Alessandra Casiraghi, Giulia Ghilardi, Giovanni Rindone, Luisa Verga, Vincenzo L’Imperio, Carlo Gambacorti Passerini, Paolo Bonfanti, Giuseppe Lapadula, Federica Cocito and Alessandro Soria
    Citation: AIDS Research and Therapy 2025 22:19
    Content type: Case Report Published on:

  35. Globally HIV remains a major public health problem. In sub-Saharan Africa most new HIV infections occur in adolescent girls and young women. Previously tested antiretroviral drugs as different pre-exposure pro...

    Authors: Nomusa M. Zondo, Parveen Sobia, Aida Sivro, Sinaye Ngcapu, Sharana Mahomed, Leila E. Mansoor, Kwabena Asare, Lara Lewis, Veron Ramsuran and Derseree Archary
    Citation: AIDS Research and Therapy 2025 22:18
    Content type: Research Published on:

  36. Anal cancer incidence is increased in people with HIV (PWH), up to 60 times higher in men who have sex with men, and almost 15 times higher among women with HIV. Screening and treating high-grade lesions (HSIL...

    Authors: Patricia Volkow, Salim Barquet-Muñoz, Naomi Jay, Maria-José Mendoza, Paulina Moctezuma, Mariel Morales-Aguirre, Delia Pérez-Montiel, Víctor Larraga and Alexandra Martin-Onraet
    Citation: AIDS Research and Therapy 2025 22:17
    Content type: Research Published on:

  38. Data about impact of switch to dolutegravir (DTG)-based antiretroviral therapy (ART) on estimated glomerular filtration rate (eGFR) in Asians are scarce. RV254/SEARCH010 is a prospective observational cohort i...

    Authors: Carlo Sacdalan, Curtis Austin, Aswathy Varma, Suteeraporn Pinyakorn, Eugène Kroon, Donn J. Colby, Phillip Chan, Orlanda Goh, Krittaporn Pornpaisakul, Jintana Intasan, Tassanee Luekasemsuk, Merlin L. Robb, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Sandhya Vasan…
    Citation: AIDS Research and Therapy 2025 22:15
    Content type: Brief Report Published on:

  39. HIV remains one of the major epidemics and public health concerns within low and middle-income countries such as Tanzania. This study aimed to assess the prevalence and the factors associated with HIV testing-...

    Authors: Jackson Micheal Asingwire, Isaac isiko, Kuli Faith Rombe, Aaron Mwesigwa, Emmanuel Asher Ikwara, Haron Olot, Lenz Nwachinemere Okoro, Manankong Jane Precious Izunwanne, Blessing Onyinyechi Agunwa, Abdul Aziiz Bwana, William Yiga Kalemba and Ebuka Louis Anyamene
    Citation: AIDS Research and Therapy 2025 22:14
    Content type: Research Published on:

  40. The purpose of this review is to characterize the combined effects of tobacco smoking and human immunodeficiency virus (HIV) infection in people with HIV (PWH) and identify possible therapeutic targets through...

    Authors: Benjamin L. Orlinick and Shelli F. Farhadian
    Citation: AIDS Research and Therapy 2025 22:13
    Content type: Review Published on:

  42. Hospitalized people living with HIV (PLWH) experienced extremely high mortality rates in the first year after an index hospitalization in the pre-Dolutegravir (DTG) era. We conducted a multi-center study in Mw...

    Authors: Godfrey A. Kisigo, Eric Barongo, Benson Issarow, Cody Cichowitz, Bahati Wajanga, Samuel Kalluvya and Robert N. Peck
    Citation: AIDS Research and Therapy 2025 22:11
    Content type: Brief Report Published on:

  43. Over the years, Nigeria has recorded significant progress in controlling the HIV epidemic in the country. HIV prevalence has reduced from 4.1% in 2010 to 1.4 in 2019. The number of people acquiring new HIV inf...

    Authors: Abdulsamad Salihu, Ibrahim Jahun, David Olusegun Oyedeji, Wole Fajemisin, Omokhudu Idogho, Samira Shehu, Aminu Yakubu and Jennifer Anyanti
    Citation: AIDS Research and Therapy 2025 22:10
    Content type: Review Published on:

    The Correction to this article has been published in AIDS Research and Therapy 2025 22:23

  44. In January 2021, the United States (US) Food and Drug Administration (FDA) approved the first long-acting injectable antiretroviral therapy (LAI ART) regimen for the treatment of HIV providing an alternative t...

    Authors: Yiyang Liu, Rebecca J. Fisk-Hoffman, Maitri Patel, Robert L. Cook and Mattia Prosperi
    Citation: AIDS Research and Therapy 2025 22:9
    Content type: Research Published on:

  45. The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutat...

    Authors: Anna Maria Doro Altan, Noorjehan Majid, Stefano Orlando, Elton Uamusse, Marcia Rafael, Zita Sidumo, Giovanni Guidotti and Fausto Ciccacci
    Citation: AIDS Research and Therapy 2025 22:8
    Content type: Research Published on:

  46. Dietary diversity is the utilization of food and food groups consumed by individuals over 24 h, which is an indicator of a diet’s micronutrient adequacy. Dietary management in people with HIV patients is the k...

    Authors: Bitew Tefera Zewudie and Yihenew Sewale
    Citation: AIDS Research and Therapy 2025 22:7
    Content type: Review Published on:

  47. Early detection and initiation of care is crucial to the survival and long-term well-being of children living with HIV (CLHIV). However, there remain challenges regarding early testing and linking of CLHIV for...

    Authors: Rindidzani E. Magobo, Musawenkosi Mabaso, Sean Jooste, Lesiba Molopa, Inbarani Naidoo, Leickness Simbayi, Khangelani Zuma, Nompumelelo Zungu, Olive Shisana and Sizulu Moyo
    Citation: AIDS Research and Therapy 2025 22:6
    Content type: Research Published on:

  48. Over the past decade, Venezuela has experienced a political and economic crisis that has affected the country’s scientific research development. Currently, the state of HIV research in Venezuela remains unknow...

    Authors: Jesús A. Morgado, María G. Medina, Rafael N. Guevara, Martín Carballo, Jaime R. Torres, Fhabián S. Carrión-Nessi and David A. Forero-Peña
    Citation: AIDS Research and Therapy 2025 22:5
    Content type: Review Published on:

  49. Female sex workers (FSWs) in Uganda experience numerous barriers to antiretroviral therapy (ART) adherence. We used the planned behavior theory to help explore the enablers and barriers to ART adherence among ...

    Authors: David Friday Apuulison, Brenda Nabawanuka, Michael Muhoozi, Julian Aryampa, Pauline Irumba, Edson Katsomyo, Moses Asiimwe, Joshua Epuitai, Pardon Akugizibwe, Wasswa George and John Rubaihayo
    Citation: AIDS Research and Therapy 2025 22:4
    Content type: Research Published on:

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AIDS Research and Therapy

ISSN: 1742-6405

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